Ebadifar A, Nomani M, Fatemi SA. Effect of nano-hydroxyapatite toothpaste on microhardness ofartificial carious lesions created on extracted teeth. J Dent Res Dent Clin Dent Prospects. 2017;11(1):14-17. doi:10.15171/joddd.2017.003 Triclosan– Triclosan is an antibacterial agent that’s linked to bacterial resistance and endocrine disruption. A popular brand of toothpaste that I used for years had Triclosan in it. Sodium lauryl sulfate (SLS)– this is associated with canker sores and perioral dermatitis (my daughter is susceptible to this hard-to-eradicate rash around the mouth). Komiyama S, Miyasaka R, Kikukawa K, Hayman R (2019) Can nano-hydroxyapatite permeate the oral mucosa? A histological study using three-dimensional tissue models. PLoS ONE 14(4): e0215681. https://doi.org/10.1371/journal. pone.0215681 My Take: This was my first time trying toothpaste that came in a tablet form. It turns out I’m super impressed with Bite Toothpaste Bits! Jeremy loved them too. You have to bite down on the bit to crush the tablet, then wet your toothbrush and start brushing. It actually produces a nice foam-like texture once you get brushing. These bits leave your mouth feeling very minty fresh. Bonus points for being eco-friendly! One thing to mention- I have very sensitive, receding gums, and I found that some of the little bits did not disintegrate, acting like a scouring agent on my gums. If you have receding gums, this may not be your best bet.

No harmful chemicals like sodium lauryl sulfate (SLS), propylene Glycol, artificial flavors, or dyes Green R, Lanphear B, Hornung R, et al. Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada [published online ahead of print, 2019 Aug 19]. JAMA Pediatr. 2019;173(10):940-948. doi:10.1001/jamapediatrics.2019.1729.

The History Of Hydroxyapatite

Our new RiseWell Pro Sensitivity Mineral Toothpaste contains both Micro and Nano-Hydroxyapatite creating a game changing formula for people who have extra sensitivity. With the most hydroxyapatite on the market, our PRO toothpaste is clean, 100% safe and incredibly effective at strengthening, remineralizing and protecting the teeth while also alleviating sensitivity. Ramis, J., Coelho, C., Cordoba, A., Quadros, P., and M. Monjo. Safety Assessment of Nano-Hydroxyapatite as an Oral Care Ingredient according to the EU Cosmetics Regulation. Cosmetics 2018, 5, 53; doi:10.3390/cosmetics5030053. Orthodontic patients in a 2016 study were treated with either a fluoride toothpaste, two brands of nano-hydroxyapatite toothpaste or a control toothpaste. The two brands of nano-hydroxyapatite toothpaste were found to be the most efficient at preventing tooth demineralization compared with the fluoride toothpaste and the control ( 5). Browning, WD, Cho, SD and EJ Deschepper. Effect of a nano-hydroxyapatite paste on bleaching-related tooth sensitivity. J Esthet Restor Dent. 2012 Aug;24(4):268-76. doi: 10.1111/j.1708-8240.2011.00437.x. Lim, T.Y. et al. Propylene Glycol Toxicity in Children. J Pediatr Pharmacol Ther. 2014 Oct-Dec; 19(4): 277–282.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997847/?_ga=2.27426748.1073827304.1599421251-2018910469.1599421251 Parabens– These preservatives prevent the growth of bacteria, but they disrupt hormone function and were able to stimulate breast cancer cell growth in a lab study. My Take: This Ela Mint Toothpaste has a really pleasant mint taste – it’s not too sweet or too zingy. It really makes my gums feel soothed after brushing, like they’ve just been hugged. I really like this toothpaste. The ingredients do state that the toothpaste product is made on the same manufacturing line as peanuts, tree nuts, dairy, eggs, and sunflower. My daughter is severely allergic to tree nuts, so this is something to consider if someone in your house has allergies. Participants in a 2012 study had their teeth bleached with a 7% hydrogen peroxide gel for 14 days. Half the group used nano-hydroxyapatite paste after bleaching, leaving it on for 5 minutes, and the placebo had a paste applied with no hydroxyapatite added. The group treated with nano-hydroxyapatite paste had significantly lower sensitivity levels than the placebo group ( 4).Amaechi BT, AbdulAzees PA, Alshareif DO, et al. Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children. BDJ Open. 2019;5:18. Published 2019 Dec 9. doi:10.1038/s41405-019-0026-8

Meyer F, Amaechi BT, Fabritius HO, Enax J. Overview of Calcium Phosphates used in Biomimetic Oral Care. Open Dent J. 2018;12:406-423. Published 2018 May 31. doi:10.2174/1874210601812010406 Singh, A., Shetty, B., Mahesh, C.M., Reddy, V., Chandrashekar, B.S., and S. Mahendra. Evaluation of Efficiency of Two Nanohydroxyapatite Remineralizing Agents with a Hydroxyapatite and a Conventional Dentifrice: A Comparative In vitro Study. Journal of Indian Orthodontic Society. Volume 51, Issue 2, April-June 2017. Powered by the highest concentration of Micro and Nano-Hydroxyapatite on the market to strengthen, remineralize and protect tooth enamel while alleviating sensitivity Our Mineral Toothpaste is powered by Hydroxyapatite creating a formula that is clean, safe and incredibly effective at strengthening, remineralizing and protecting the teeth.In a 2017 study measuring tooth hardness, demineralized tooth surface coated with hydroxyapatite toothpaste was found to be harder after 2 weeks of application than tooth surface coated with fluoride toothpaste alone ( 6).